Yumi Konagaya

Project Member
Quantitative Biology of Cell Fate Decision

The team aims to elucidate the tissue geometry-dependent maintenance of stem cell niches using intestinal organoids as a model. To investigate the effect of tissue morphological changes on niche maintenance, they will control the geometrical features of the extracellular matrix by micropatterning technique. Furthermore, they will uncover the molecular and mechanical mechanisms underlying the self-assembly of stem cells. This research has the potential to reveal the mechanism of stem cell niche maintenance that universally exists in various tissues beyond intestinal epithelium.